Nanotechnology and Biosynthesis of Secondary Metabolites Team
Leader
Assoc. Prof. Gregory Franklin
Staff
Selvakesavan Rajendran Kamalabai, PhD
Veeresh Lokesh, PhD (assistant)
Dariusz Kruszka, MSc (PhD student)
Matam Pradeep, MSc (PhD student)
The research conducted in the team concerns various issues and is conducted on Hypericum perforatum.
Research profile
- Mechanisms of plant resistance against T-DNA transfer,
- Nanotechnology in plants.
Methods:
- plant transformation using A. tumefaciens HPLC
Current research activities
Selected papers
- Marslin G., Sarmento B.F.C.C., Franklin G., Martins J.A.R., Silva C.J.R., Gomes A.F.C., Sárria M.P., Coutinho O.M.F.P., Dias A.C.P. (2017). Curcumin Encapsulated into Methoxy Poly(Ethylene Glycol) Poly(ε-Caprolactone) Nanoparticles Increases Cellular Uptake and Neuroprotective Effect in Glioma Cells. Planta Medica 83(5):434-444. DOI: http://dx.doi.org/10.1055/s-0042-112030
- Marslin G., Sheeba C.J., Franklin G. (2017). Nanoparticles Alter Secondary Metabolism in Plants via ROS Burst. Frontiers in Plant Science. 83 (5): 434-444. DOI: 10.3389/fpls.2017.00832
- Shakya P., Marslin G., Siram K., Beerhues L., Franklin G. (2017). Elicitation as a tool to improve the profiles of high-value secondary metabolites and pharmacological properties of Hypericum perforatum. Journal of Pharmacy and Pharmacology published by John Wiley & Sons Ltd. doi: 10.1111/jphp.12743
- Hou W., Shakya P., Gregory F. (2016). A Perspective on Hypericum perforatum genetic transformation. Frontiers in Plant Science doi: 10.3389/fpls.2016.00879
- Siram K., Raghavan C.V., Marslin G., Rahman H., Divakar S., Balakumar K. Gregory F. (2016). Quillaja saponin: A prospective emulsifier for the preparation of solid lipid nanoparticles. Colloids and surfaces B: Biointerfaces DOI: 10.1016/j.colsurfb.2016.07.065
- Siram K., Marslin G., Raghavan Ch. V., Balakumar K., Rahman H., Franklin G. (2016). A brief perspective on the diverging theories of lymphatic targeting with colloids. International Journal of Nanomedicine 11: 1-6.
- Franklin G., Beerhues L., Cellárová E. (2016). Molecular and biotechnological advancements in Hypericum species. Frontiers in Plant Science. 7: 1687. DOI: 10.3389/fpls.2016.0168
Grants
Project no: 2016/21/B/NZ9/01980
Project title: Hyperisyn - The use of innovative research tools to understand the molecular and genetic conditions of the hypericin biosynthesis pathway
Principal investigator: F. Gregory
Duration: 5 July 2017 - 4 July 2020
Project no: 2016/21/B/NZ9/01980
Project title: HyperAgro:HyperNano - Investigation of changes in secondary metabolism in Hypericum perforatum under the influence of nanoparticles through the use of an integrated 'omics' approach and technology
Prinicipal investigator: F. Gregory
Duration: 12 January 2017 - 11 January 2020
- Project no: 2017/25/B/NZ9/00720
Project title: HyperAgro: Hypericum-Agrobacterium interaction as a model to understand the phenomenon of plant resistance to T-DNA transfer
Principal investigator: F. Gregory
Duration: February 2018 - February 2021